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Gamma-aminobutyric acid (GABA) stands as one of the primary inhibitory neurotransmitters in the central nervous system, counteracting the excitatory impact of glutamate on neuronal activity. Recognized for its inhibitory effects, GABA is generally acknowledged to alleviate anxiety, induce muscle relaxation, and exhibit sedative-like effects. Additionally, GABA has demonstrated the ability to significantly increase alpha brain waves, associated with a heightened state of relaxation and improved concentration.
In a clinical trial involving individuals with acrophobia, the control group crossing a suspension bridge experienced a 35% reduction in salivary levels of secretory immunoglobulin A (sIgA), a marker indicating stress-related declines in immune system activity. Conversely, participants who crossed the same bridge while taking GABA-Pro witnessed increases in sIgA levels, suggesting a stress-reducing effect.
Numerous medications used to address insomnia target GABA receptors and activity, resulting in outcomes such as decreased wakefulness, reduced sleep latency, and increased slow-wave sleep.
Pharma GABA, characterized by high absorption and the ability to bind to GABA receptors in the peripheral nervous system (PNS), plays a role in the autonomic nervous system (ANS) responsible for triggering the "relaxation response," contrasting the "fight or flight" response. In a double-blind crossover study, individuals taking 30 mg of Pharma GABA per meal after an overnight fast demonstrated significant increases in overall ANS and PNS activities compared to a placebo. This implies that Pharma GABA may induce relaxation effects by modulating ANS activity.
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